易忠勝，教授，理學博士，博士研究生導師
1970年6月出生。主要從事分析化學、理論環境化學和計算環境毒理學方面的教學與研究工作，中國毒理學會計算毒理專業委員會委員，中國化學會會員，中國毒理學會會員，擔任廣西/江西/河北/海南省科技項目評審專家，Chemical Engineering Journal，Environment International，Chemosphere，Food Chemistry，Journal of the Science of Food and Agriculture等學術期刊的評審專家。先後主持國家自然科學基金項目4項，廣西自然科學4項，863計劃子項目1項，國家重點實驗開放基金1項。在International Journal of Biological Macromolecules，Chemosphere，Analytical and Bioanalytical Chemistry等權威學術期刊發表SCI論文40餘篇。
近期發表的代表論著:
1. Wangli Miao, Dan Jia, Jie Xu, Li Yong, Zhongsheng Yi*. Probing the binding interactions between perfluoroalkyl carboxylic acids and adenosine A2A receptors by spectroscopic techniques, molecular simulations and quantum chemistry. Journal of Molecular Liquids. 2023, 377: 121565. (https://doi.org/10.1016/j.molliq.2023.121565， https://authors.elsevier.com/a/1giH-c8qpaSmf)
2. Wangli Miao, Dan Jia, Yuefan Rui, Wenhui Liang, Yanting Chen, Hongyan Liu, Zhongsheng Yi*. Interaction Mechanisms of the Binding of Polychlorinated Biphenyls to Thyroid Hormone Transporters Revealed based on Quantum Chemistry and Spectroscopy. Journal of Molecular Structure. 2023, 1281: 135104. (https://doi.org/10.1016/j.molstruc.2023.135104, https://authors.elsevier.com/a/1gZgU54JUV0U6)
3. Dan Jia, Wangli Miao, Yuefan, Rui, Yanting Chen, Wenhui Liang, ZhongshengYi*. Thyroid hormone transporters binding affinity of methoxypoly chlorinated biphenyls: Insights from molecular simulations and fluorescence competitive binding experiment. International Journal of Biological Macromolecules. 2023, 231: 123224 (https://doi.org/10.1016/j.ijbiomac.2023.123224)
4. Dan Jia, Wangli Miao, Muwei Huang, Xiaomei Huang, Zhongsheng Yi*. Investigations on the binding properties of hydroxylated polybrominated diphenyl ethers with lysozyme using the multispectral techniques and molecular modeling. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2023: 121864. (https://doi.org/10.1016/j.saa.2022.121864).
5. Muwei Huang, Xiaomei Huang, Li Yong, Dan Ja, Wangli Miao, Hongyan Liu*, Zhongsheng Yi*. Insight on the microscopic binding mechanism of bisphenol compounds (BPs) with transthyretin (TTR) based on multi-spectroscopic methods and computational simulations. Analytical and Bioanalytical Chemistry (Paper in Forefront). 2022. 414(13): 3765-3780. (https://doi.org/10.1007/s00216-022-04028-0, https://rdcu.be/cKYoz; https://rdcu.be/cLmTQ)
6. Xiaomei Huang, Muwei Huang, Li Yong, Dan Jia, Wangli Miao, Zhongsheng Yi*, Hongyan Liu*. Study on Spectral Method and Computational Simulation of Chlorinated Bisphenol Compound and Thyroxine-Binding Globulin. ChemistrySelect. 2022, 7(11): e202104376 (https://doi.org/10.1002/slct.202104376) (https://onlinelibrary.wiley.com/share/author/QZKAFUIZYS87FSQFA9FI?target=10.1002/slct.202104376)
7. Wei Yuchen, Xu Jie, Huang Muwei, Rui Yuefan, Wu Zhiwei, Yi Zhongshengsheng*. Photophysical properties and dynamics simulation of the interaction between human serum albumin and hydroxy polybrominated diphenyl ether[J]. Spectroscopy Letters, 2022, 55(2): 114-127. (https://doi.org/10.1080/00387010.2022.2029492)
8. Muwei Huang, Xiaomei Huang, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Exploring the toxic effects and mechanism of methoxylated polybrominated diphenyl ethers (MeO-PBDEs) on thyroxine-binding globulin (TBG): Synergy between spectroscopic and computations. Luminescence, 2021, 36(7): 1621-1631. (http://doi.org/10.1002/bio.4103)
9. Manting Huang, Li Yong, Jie Xu, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Determinants of Adenosine A2A Receptors‐Perfluoroalkyl Sulfonates Complex: Multi‐Spectroscopic and Molecular Dynamics Simulation Study[J]. Chemistryselect. 2021, 6(19): 4633-4644. (http://dx.doi.org/10.1002/slct.202100863). (https://onlinelibrary.wiley.com/share/author/IBZMMV5JR3NK2B48T7NM?target=10.1002/slct.202100863)
10. Xiaomei Huang, Muwei Huang, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Binding characteristics of hydroxylated polybrominated diphenyl ether with thyroid protein and its potential toxicity[J]. Journal of Molecular Structure. 2021, 1236:130285. (https://doi.org/10.1016/j.molstruc.2021.130285)
11. Rui Yuefan, Zuo Yanqiu, Yang Lulu, Xu Jie, Wei Yuchen, Zhongsheng Yi*, Molecular dynamics and spectral analysis for the binding of methoxylated polybrominated diphenyl ethers to lysozyme[J]. Journal of Molecular Structure. 2020, 1226: 129329 (https://doi.org/10.1016/j.molstruc.2020.129329)
12. Yong Li, Huang Manting, Wei Yuchen., Xu Jie, Yi Zhongsheng*. Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled estrogen receptor: spectroscopic analyses and computational simulations[J]. Analytical Methods, 2020, 12(31): 3944-3953. (https://doi.org/10.1039/D0AY01052A)
13. Zuo Yanqiu, Yi Zhongsheng*, Xu Jie, Rui Yuefan, Wei Yuchen, Liu Hongyan. Molecular simulation and spectroscopic studies on the interaction between perfluorohexadecanoic acid and human serum albumin[J]. Indian J. Biochem. Biophys., 2019, 56(3): 185-192.
14. Zuo Yanqiu, Rui Yuefan, Xu Jie, Yang Llu, Yi Zhongsheng.* Multi-spectroscopic and molecular dynamics simulations investigation of the binding mechanism of polybrominated diphenyl ethers to hen egg white lysozyme[J]. Luminescence, 2019, 34(7): 749-758. (https://doi.org/10.1002/bio.3669)
15. Yang Lulu, Yang Wu, Yi Zhongsheng, Zhao Sai, Duan Jiaxi. Study on the Interaction of Tetra-Brominated Diphenyl Ethers (BDE47) with Lysozyme[J]. Spectrosc. Spectr. Anal., 2019, 39(11): 3614-3618. (http://www.gpxygpfx.com/article/2019/1000-0593-39-11-3614.html)
16. Li Jiao., Xu Jie, Jin Wenying, Yi Zhongsheng*, Cai Chenbo, Huang Xuefen, Nie Jjinfang, Zhang Yun. Fluorescent kinetics combined with fourth-order calibration for the determination of diclofenac sodium in environmental water[J]. Analytical and Bioanalytical Chemistry, 2019, 411(10): 2019-2029. (https://doi.org/10.1007/s00216-019-01624-5)
17. Liu Hongyan*, Zhang Zexiong, Xie Shiwei, Xin He, Zhu Yinian, Li Haiyun, Yi Zhongsheng*. Study on transformation and degradation of bisphenol A by Trametes versicolor laccase and simulation of molecular docking[J]. Chemosphere, 2019, 224: 743-750. (https://doi.org/10.1016/j.chemosphere.2019.02.143)
18. XuJie, WeiYuchen, Yang Wu, Yang Lulu, Yi Zhongsheng*.*The Mechanism and Conformational Changes of Polybrominated Diphenyl Ethers to TTR By Fluorescence Spectroscopy, Computer Simulation, and Quantum Chemical. Analyst. 2018, 143(19): 4662-4673. (https://doi.org/10.1039/C8AN00435H)
19. 徐婕，魏雨晨，伍智蔚，易忠勝*. 基于酸度誘導的HSA與BDE154的光譜和計算模拟研究. 化學學報. 2018, 76(5): 408-414. (https://doi.org/10.6023/A18020060)
20. Wei Yuchen, Yi Zhongsheng*, Xu Jie, Yang Wu, Yang Lulu, Hongyan Liu*. Study on the binding characteristics of hydroxylated polybrominated diphenyl ethers and thyroid transporters using the multispectral technique and computational simulation. J. Biomol. Struct. Dyn., 2019, 37(6): 1402-1413. (https://doi.org/10.1080/07391102.2018.1461134)
21. Xu Jie., Yi Zhongsheng*, Wei Yuchen, Yang Wu, Yang Lulu, Nie Jinfang. Probing the Binding Mechanism of Polybrominated Diphenyl Ethers with Transthretin by Multi-Spectroscopic and Molecular Dynamics Simulations (J). Analytical Methods, 2017, 9(26): 3929-3940. (https://doi.org/10.1039/C7AY00838D)
22. Yang Wu, Yang Lulu, Yi Zhongsheng*, Wu Zhiwei, Nie Jinfang, Zhang Aiqian. Investigating the affinity of BDE154 and 3OH-BDE154 with HSA: Experimental and simulation validation (J). Environmental Toxicology and Pharmacology, 2017, 51: 85-93. (https://doi.org/10.1016/j.etap.2017.03.004)
23. Yang Lulu, Yang Wu, Wu Zhiwei, Yi Zhongsheng*. Binding of hydroxylated polybrominated diphenyl ethers with human serum albumin: Spectroscopic characterization and molecular modeling (J). Luminescence, 2017, 32(6): 978–987. (https://doi.org/10.1002/bio.3280)
24. 楊露露, 楊霧, 伍智蔚, 易忠勝*. 計算模拟與光譜法研究 4-羟基-2, 2’, 3, 4’-四溴二苯醚與人血清白蛋白的相互作用(J). 化學通報, 2017, 80(2), 185-190.
25. 董露, 易忠勝*, 伍智蔚, 王海洋, 張愛茜. 結合光譜法和計算模拟多角度分析2,2',4,4',5⁃五溴二苯醚與人血清白蛋白的作用機制(J). 環境科學學報, 2016, 36(1), 332-339. (https://www.actasc.cn/hjkxxb/ch/reader/create_pdf.aspx?file_no=20150315001&year_id=2016&quarter_id=1&falg=1)
26. 伍智蔚, 易忠勝*, 董露, 楊露露, 楊霧, 張愛茜. 模拟和光譜相互驗證2'-OH-BDE-28對HSA構象的影響(J). 生态毒理學報, 2016, 11(1), 159-166. (http://www.stdlxb.cn/article/doi/10.7524/AJE.1673-5897.20150513001?viewType=HTML)
27. Wu Zhiwei, Yi Zhongsheng*, Dong Lu, Zhang Aiqian. Molecular simulation study of the specific combination between four kinds of phthalic acid esters and human serum albumin (J). Environmental Toxicology and Pharmacology, 2016, 41: 259-265. (https://doi.org/10.1016/j.etap.2015.12.017)
28. 董露, 易忠勝*, 伍智蔚, 王海洋, 張愛茜. 2'-羟基-2, 4-二溴二苯醚與人血清白蛋白作用機制的光譜研究與計算模拟(J). 高等學校化學學報, 2015, 36(3), 516-522. (http://www.cjcu.jlu.edu.cn/CN/10.7503/cjcu20141007)
29. 蒙延娟, 易忠勝*, 艾芳婷, 張愛茜. 基于對接的植物激素3D-QSAR和分子動力學模拟(J). 環境化學, 2014, 33(6), 880-890.
30. Yi Zhongsheng*, Zhang Aiqian. A QSAR Study of Environmental Estrogens Based on a Novel Variable Selection Method (J). Molecules, 2012, 17(5), 6126-6145. (https://doi.org/10.3390/molecules17056126)
31. Nie Jinfang*, Zhang Yun, Yi Zhongsheng, Zou Hongyan, Fu Haiyan, Wu Hailong. Advanced chemometric algorithm coupled to subspace projection technique between original and pseudo samples: A snapshot of chemical rank estimation for high-order data (J). Chemometr. Intell. Lab. Syst., 2012, 118(1), 211-218. (https://doi.org/10.1016/j.chemolab.2012.06.003)
32. Yi Zhongsheng*, Li Lianchen, Zhang Aiqian, Wang L. New Modes for the Prediction of Gas Chromatographic Relative Retention Times of Polybrominated Diphenyl Ethers (J). Chin. J. Chem, 2011, 29(11), 2495-2504. (https://doi.org/10.1002/cjoc.201100039)
近年主持和參與的項目：
1. 2022.04-2025.03，有機磷酸酯與G蛋白偶聯雌激素受體結合機制研究，廣西科技計劃項目，2022GXNSFAA035448，主持，廣西科技廳
2. 2022.01-2025.12，酚、酯類污染物與G蛋白偶聯雌激素受體結合機制及結構依賴性研究，國家自然科學基金，22166015，主持，國家基金委
3. 2019.01-2022.12，鹵代酚類有機污染物與甲狀腺蛋白作用的分子機制研究，國家自然科學基金，21866011，主持，國家基金委
4. 2017-09-2020-09，多溴二苯醚及其衍生物與甲狀腺轉運蛋白結合作用研究，廣西科技計劃項目，2017GXNSFAA198354，主持，廣西科技廳
5. 2015-01-2018-12，白腐真菌P450酶對雙酚A類的降解及計算機分子模拟研究，國家自然科學基金，21467006，參與，國家基金委
6. 2014.01-2017.03，雙酚A與P450酶相互作用的分子模拟與構效關系研究，廣西科技計劃項目，2014GXNSFAA118034，參與，廣西科技廳
7. 2013.01-2015-12，有機磷系阻燃劑毒性的QSAR評價技術（863計劃子項目，有機磷系阻燃劑的環境監測與毒性效應評價技術，2013AA065201），主持，國家科技部
8. 2013.04-2016-03，多溴二苯醚與人血清白蛋白的相互作用研究，廣西自然科學基金，2013GXNSFAA019034，主持，廣西科技廳
9. 2013.01-2015.12，全氟化合物與人血清白蛋白的相互作用研究，博士啟動基金，主持，太阳成tyc9728
10. 2013.01-2016.12, 典型環境PBDEs 與人血清白蛋白的相互作用及其構效關系研究，國家自然科學基金，21267008，主持，國家基金委
11. 2012-01-2015-04，多組分熒光免疫分析結合化學計量學方法用于生物體液中多項腫瘤标記物的無幹擾同時定量檢測，廣西自然科學基金項目，2012GXNSFBA053029，參與，廣西科技廳
12. 2012-01-2015-05，基于二階校正的三維熒光分析用于藥物與DNA的相互研究，廣西高等學校科研項目，201203YB090，參與，廣西教育廳
13. 2012.01-2013.12，PBDEs 與P450 相互作用的模拟研究，環境化學與生态毒理學國家重點實驗室開放基金，KF2011-21，主持，環境化學與生态毒理學國家重點實驗室
14. 2012.01-2015.12，典型環境PBDE 酶促代謝及其構效關系研究，國家自然科學基金，21167006，主持，國家基金委
15. 2011.03-2014.03, 典型環境PBDEs 酶促代謝機理的實驗與模拟研究，廣西自然科學基金，2011GXNSFA018061，主持，廣西科技廳
申請專利：
1. 張愛茜，易忠勝，穆雲松，蔺遠，高常安，李富華. 污染物定量結構活性相關模型結構描述符篩選終止的方法，2011.08，申請号：CN 102156791 A
2. 張愛茜，易忠勝，李富華，蔺遠，高常安，穆雲松. 有機污染物定量結構活性相關模型抽多法交叉驗證方法，2011.09，申請号：CN 102184284 A
3. 易忠勝，劉紅豔，莫淩雲. 有機污染物定量構效活性相關建模的變量篩選方法，2012.05，申請号：CN 102682209 A
4. 劉紅豔，邢賀，馬钰，張澤雄，易忠勝，一種利用白腐真菌粗酶液降解雙酚E的方法，申請日：2017.04.18，公開号: CN107096160A
5. 陶慧林，廖秀芬，徐銘澤，謝襄漓，鐘福新，易忠勝，一種檢測人血清中痕量免疫球蛋白G濃度的方法，申請日：2014.05.11，公開号 : CN103969446A
6. 陶慧林，廖秀芬，徐銘澤，黎舒懷，鐘福新，易忠勝，一種快速檢測河水中痕量Hg2+濃度的方法，申請日 : 2014.05.11，公開号 : CN103969237A
7. 陶慧林，廖秀芬，孫超，謝襄漓，鐘福新，易忠勝，黃藝鵬，利用熒光碳點與碲化镉量子點能量轉移技術檢測農田水中綠麥隆含量的方法，申請日 : 2014.04.16，公開号 : CN103901007A
8. 陶慧林，徐銘澤，易忠勝，張慶軍，艾芳婷，陳杵序，利用開關型熒光能量轉移體系檢測多溴聯苯醚殘留的方法，申請日 : 2013.10.15，公開号 : CN103487417A
計算機軟件著作權：
1. 環境内分泌幹擾物活性預測和模式識别系統軟件(EDCAPPR)，2011SR002274，2011.01.17，國家版權局
2. 通用變量篩選與建模程序(GVSMP)，2015SR123587，2015.07.03，國家版權局
3. LIBSVM_Assistant，2015SR206681，2015.10.27，國家版權局
4. Molcular Descriptor Calculator，2016SR025450，2016.02.02，國家版權局
