聶瑾芳，漢族，1983年出生于湖南。博士/博士後，教授，碩士研究生導師
研究領域：化學生物傳感、化學計量學。E-mail：god78@163.com；Niejinfang@glut.edu.cn。
（一）教育與工作經曆
2011.03-至今：太阳成tyc9728，太阳成tyc9728，副教授（2012）、教授（2017）；
2016.03-2016.09：廣西科學技術廳（挂職），基礎研究處副處長；
2014.11-2015.11：英國牛津大學（University of Oxford），化學系，博士後（合作導師：Tom Brown 教授）；
2005.09-2010.12：湖南大學，化學生物傳感與計量學國家重點實驗室，分析化學專業，獲理學博士學位（導師：吳海龍教授、俞汝勤院士）；
2001.09-2005.07：湖南大學，化學化工學院，應用化學專業，獲理學學士學位（導師：吳海龍教授）。
（二）教學工作
本科生課程：《分析化學》、《計算機在分析化學中的應用》、《環境分析化學》、《精細化學品化學》、《食品化學與分析》；研究生課程：《分子科學計算基礎》、《環境污染化學》。主持建設的《分析化學》中英文雙語在線開放課程于2018年5月在“學堂在線”主站平台上線。目前，來自中國、美國、英國、意大利等世界各國的在線選課人數超過1.74萬（截至2019年5月）。
代表性教學/教改獲獎：
2018年度教育部在線研究中心“智慧教學之星”
太阳成tyc9728第十四屆十佳青年授課教師
太阳成tyc97282013年度優秀青年授課老師
第十一屆全國多媒體課件大賽優秀獎
第十二屆全國多媒體課件大賽優秀獎
第十二屆廣西區教育教學軟件大賽二等獎
第八屆廣西高校教學軟件大賽優秀獎
太阳成tyc97282013年首屆微課教學比賽二等獎
太阳成tyc9728第二屆多媒體教學軟件比賽二等獎
太阳成tyc9728第三屆多媒體教學軟件比賽二等獎
太阳成tyc9728“欣羽創新人才發展獎”
太阳成tyc97282014年度優秀班導師
指導本科生/研究生獲獎：
第12屆全國電分析化學學術會議論文牆展二等獎
2014年度廣西區優秀碩士畢業生
2015年度廣西高校化學化工類論文及設計競賽一等獎
桂林市第二屆優利特杯大學生科技創新設計大賽一等獎
太阳成tyc97282014年度優秀碩士畢業生
太阳成tyc97282017年度優秀碩士學位論文
（三）科研工作
主持國家自然科學基金項目3項、廣西重點研發計劃項目1項、廣西自然科學基金項目1項、廣西高等學校科研項目1項、太阳成tyc9728博士科研啟動基金項目1項。在Analytical Chemistry、Chemical Communications、Biosensors and Bioelectronics、Chemometrics and Intelligent Laboratory Systems、Journal of Chemometrics等分析化學領域國際主流期刊發表SCI收錄論文50餘篇，其中影響因子大于4的期刊論文26篇、封底論文3篇。論文他引近1200篇次（單篇最高被引123次），個人H因子為20。研究成果被科技媒體X-MOL專題報道2次。作為主要成員參與譯著《化學計量學實用指南》。獲授權中國發明專利3項。
主持的科研項目：
“基于靈敏調控紙潤濕性機制的重金屬免儀器快速定量檢測新方法研究”，國家自然科學基金項目，項目批準号21765007，執行年限2018-2021
“基于雜交鍊式反應和三階校正的轉錄因子高靈敏熒光檢測新方法研究”，國家自然科學基金項目，項目批準号21565012，執行年限2016-2019
“基于圖案化紙和超疏水效應抑制背景信号的核酸适配體生物分析新方法研究”，國家自然科學基金項目，項目批準号21205021，執行年限2013-2015
“水環境重金屬免儀器快速定量檢測技術開發及應用”，廣西重點研發計劃項目，項目編号桂科AB17129003，執行年限2017-2020
“多組分熒光免疫分析結合化學計量學方法用于生物體液中多項腫瘤标記物的無幹擾同時定量檢測”，廣西自然科學基金項目，項目批準号2012GXNSFBA053029，執行年限2012-2014
“基于二階校正的三維熒光分析用于藥物與DNA的相互研究”，廣西高等學校科研項目，項目批準号201203YB090，執行年限2012-2014
“複雜體系中多維數據解析的化學計量學方法研究”，太阳成tyc9728博士科研啟動基金項目，項目批準号002401003337，執行年限2011-2014
（四）主要學術與社會兼職
教育部學位與研究生教育發展中心學位論文評審專家；廣西發展戰略研究會專家；廣西科技計劃項目評審專家；2018年廣西職業院校信息化教學大賽評委；Journal of Chromatogrphy B、Applied Surface Science、Electrophoresis等國際SCI期刊審稿專家。
（五）代表性學術論文（*通訊作者）
1. Wencheng Xiao, Yiming Gao, Yun Zhang,* Jiao Li, Zhaoying Liu, Jinfang Nie,* Jianping Li. Enhanced 3D paper-based devices with a personal glucose meter for highly sensitive and portable biosensing of silver ion. Biosensors and Bioelectronics, 2019, 137, 154-160.
2. Haiyan Fu,* Qiaobo Yin, Huili Wang, Jinfang Nie, Wencheng Xiao, Zhaoying Liu, Yijing Chen, Yun Zhang.* Target-triggered in situ autocatalysis in nanopore membrane for point-of-care testing of sub-nanomolar Ag+. Sensors and Actuators: B. Chemical, 2019, 287, 290-295.
3. Jiao Li, Jie Xu, Wenying Jin, Zhongsheng Yi,* Chenbo Cai, Xuefen Huang, Jinfang Nie* and Yun Zhang. Fluorescent kinetics combined with fourth-order calibration for the determination of diclofenac sodium in environmental water. Analytical and Bioanalytical Chemistry, 2019, 411(10), 2019-2029.
4. Lang Zhang†, Yali Yuan†, Yun Zhang,* Zhaoying Liu, Wencheng Xiao, Jinfang Nie*, and Jianping Li. Equipment-Free Quantitative Aptamer-Based Colorimetric Assay Based on Target-Mediated Viscosity Change. ACS Omega, 2018, 3(2), 1451-1457.
5. 王兵月, 樂惠澤, 聶瑾芳,* 肖文成, 劉召應, 張雲.* 基于目标介導納米金凝集的Ag+目視檢測方法. 化學傳感器, 2018, 1, 48-54. 封面論文.
6. H. L. Wang, Y. Zhang,* R. X. Li, J. F. Nie,* A. H. El-Sagheer, T. Brown, Z. Y. Liu and W. C. Xiao. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical Communications, 2017, 53, 8407-8410. 封底論文.
7. J. H. Yang, Y. Zhang,* L. Zhang, H. L. Wang, J. F. Nie,* Z. X. Qin, J. Li and W. C. Xiao. Analyte-triggered autocatalytic amplification combined with gold nanoparticle probes for colorimetric detection of heavy-metal ions. Chemical Communications, 2017, 53, 7477-7480.
8. H.Y. Fu,* J.H. Yang, L. Guo, J.F. Nie,* Q.B. Yin, L. Zhang, Y. Zhang.* Using the Rubik's Cube to directly produce paper analytical devices for quantitative point-of-care aptamer-based assays. Biosensors and Bioelectronics, 2017, 96, 194-200.
9. S.W. Le, H. Zhou, J.F. Nie,* C.H. Cao, J.N. Yang,* H.C. Pan, J.P. Li and Y. Zhang.* Fabrication of paper devices via laser-heating-wax-printing for high-tech enzyme-linked immunosorbent assays with low-tech pen-type pH meter readout. Analyst, 2017, 142, 511-516.
10. L. Zhang, J.F. Nie,* H.L. Wang, J.H. Yang, B.Y. Wang, Y. Zhang* and J.P. Li. Instrument-free quantitative detection of alkaline phosphatase using paper-based devices. Analytical Methods, 2017, 9, 3375-3379
11. Nie J. F., Brown T., Zhang Y.* New two dimensional liquid-phase colorimetric assay based on old iodine–starch complexation for the naked-eye quantitative detection of analytes. Chemical Communications, 2016, 52: 7454-7457. 封底論文; 被X-MOL專題報道.
12. Zhang Y.,* Yang J. N., Nie J. F.,* Yang J. H., Gao D., Zhang L., Li J. P. Enhanced ELISA using a handheld pH meter and enzyme-coated microparticles for the portable, sensitive detection of proteins. Chemical Communications, 2016, 52: 3474-3477. 封底論文; 被X-MOL專題報道.
13. Zhang Y.,* Gao D., Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Yang J. N., Li J. P. Naked-eye quantitative aptamer-based assay on paper device. Biosensors and Bioelectronics, 2016, 78: 538-546.
14. Nie J. F.,* Li B., Zhang Y.,* Fan J. L., Yi Z. S., Cai Z. R. High-order calibration for the spectrofluorimetric determination of pesticides based on photochemical derivatization. A solution of the problems of inner-filter effects and matrix interferences in complex environmental water. Chemometrics and Intelligent Laboratory Systems, 2016, 156: 36-53.
15. Zhang Y.,* Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Gao D., Yang J. N., Zhang S. B., Li J. P. Timing readout in paper device for quantitative point-of-use hemin/G-quadruplex DNAzyme-based bioassays. Biosensors and Bioelectronics, 2015, 73: 13-18.
16. Zhang Y.,* Zhou C. B., Nie J. F.,* Le S. W., Qin Q., Liu F., Li Y. P. Equipment-free quantitative measurement for microfluidic paper-based analytical devices fabricated using the principles of movable-type printing. Analytical Chemistry, 2014, 86(4): 2005-2012.
17. Zhang Y.,* Liu F., Nie J. F.,* Jiang F. Y., Zhou C. B., Yang J. N., Fan J. L., Li J. P. An electrochemical sensing platform based on local repression of electrolyte diffusion for single-step, reagentless, sensitive detection of a sequencespecific DNA-binding protein. Analyst, 2014, 139(9): 2193-2198.
18. Nie J. F., Liang Y. Z., Zhang Y.,* Le S. W., Li D. N., Zhang S. B. One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices. Analyst, 2013, 138(2): 671-676.
19. Nie J. F., Zhang Y.,* Lin L. W., Zhou C. B., Li S. H., Zhang L. M., Li J. P. Low-cost fabrication of paper-based microfluidic devices by one-step plotting. Analytical Chemistry, 2012, 84(15): 6331-6335.
20. Nie J. F., Zhang Y.,* Wang H., Wang S. P., Shen G. L. Superhydrophobic surface-based magnetic electrochemical immunoassay for detection of Schistosoma japonicum antibodies. Biosensors and Bioelectronics, 2012, 33(1): 23-28.
21. Nie J. F., Zhang Y.,* Yi Z. S., Zou H. Y., Fu H. Y., Wu H. L. Advanced chemometric algorithm coupled to subspace projection technique between original and pseudo samples: A snapshot of chemical rank estimation for high-order data. Chemometrics and Intelligent Laboratory Systems, 2012, 118: 211-218.
22. Shao S. Z., Wu H. L.,* Li S. F., Nie J. F., Wang K. Y., Liang Y., Yu R. Y. Determination of levodopa in both human Urine and plasma samples using excitation–emission matrix fluorescence coupled with second-order calibration. Journal of Analytical Science, 2012, 24: 373-378.
23. Zhang Y., Wang H.,* Li J. P., Nie J. F., Zhang Y. W, Shen G. L.,* Yu. R. Q. Nitrocellulose strip array assembled on superhydrophobic surface: An aqueous solution diffusion-localized platform for multianalyte immunogold staining assays. Biosensors and Bioelectronics, 2011, 26 (7): 3272-3277.
24. 聶瑾芳, 吳海龍*, 張雲, 劉亞娟, 王建瑤, 李勇, 俞汝勤. 三線性分解方法用于激發-發射矩陣熒光數據中一階瑞利散射的扣除. 中國科學: 化學, 2011 , 41(11): 1740-1749.
25. Fu H. Y., Wu H. L.*, Yu Y. J., Yu L. L., Zhang S. R., Nie J. F., Li S. F., Yu R. Q. A new third-order calibration method with application for analysis of four-way data arrays. Journal of Chemometrics, 2011, 25: 408-429.
26. Yu Y. J., Wu H. L.*, Nie J. F., Zhang S. R., Li S. F., Li Y. N., Zhu S. H., Yu R. Q. A comparison of several trilinear second-order calibration algorithms. Chemometrics and Intelligent Laboratory Systems, 2011, 106: 93-107.
27. Liu Y. J., Wu H. L.,* Kang C., Gu H. W., Nie J. F., Li S. S., Su Z. Y., Yu R. Q. Four-way self-weighted alternating normalized residue fitting algorithm with application for the analysis of serotonin in human plasma. Analytical Sciences, 2011, 28(11): 1097-1104.
28. Nie J. F., Wu H. L.,* Wang J. Y., Liu Y. J., Yu. R. Q. Chemical rank estimation for excitation-emission matrix fluorescence data by region-based moving window subspace projection technique and Monte Carlo simulation. Chemometrics and Intelligent Laboratory Systems, 2010, 104: 271-280.
29. Nie J. F., Wu H. L.*, Zhang S. R., Yu Y. J., Yu R. Q. Self-weighted alternating normalized residue fitting algorithm with application to quantitative analysis of excitation-emission matrix fluorescence data. Analytical Methods, 2010, 2: 1918-1926.
30. Li S. F., Wu H. L.*, Yu Y. J., Li Y. N., Nie J. F., Fu H. Y., Yu R. Q. Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm. Talanta, 2010, 81: 805-812.
31. Cai C. B., Xu L., Han Q. J., Wu H. L., Nie J. F., Fu H. Y., Yu R. Q.* Combining the least correlation design, wavelet packet transform and correlation coefficient test to reduce the size of calibration set for NIR quantitative analysis in multi-component systems. Talanta, 2010, 81: 799-804.
32. Zou H. Y., Wu H. L.*, Fu H. Y., Tang L. J., Xu L., Nie J. F., Yu R. Q. Variable-weighted least-squares support vector machine for multivariate spectral analysis. Talanta, 2010, 80: 1698-1701.
33. Zou H. Y., Wu H. L.,* Li Y. N., Nie J. F., Fu H. Y., Li S. F., Ouyang L. Q., Yu R. Q. Simultaneous determination of dextromethorphan and quinidine in biological fluids by excitation-emission matrix fluorescence coupled with second-order calibration methods. Analytical Letters, 2010, 43, 2739-2750.
34. Li S. F., Wu H. L.,* Huang L., Li Y. N., Nie J. F., Zhang S. R., Yu R. Q. Quantitative analysis of fluphenazine hydrochloride in human urine samples using excitation-emission matrix fluorescence based on oxidation derivation and combined with second-order calibration methods. Analytical Methods, 2010, 2, 1069-1077.
35. Fu H. Y., Wu H. L.,* Zou H. Y., Tang L. J., Xu L, Cai C. B., Nie J. F., Yu R. Q. Automatic configuration of optimized sample-weighted least-squares support vector machine by particle swarm optimization for multivariate spectral analysis. Analytical Methods, 2010, 2: 282-288.
36. Fu H. Y., Wu H. L.,* Nie J. F., Yu Y. J., Zou H.Y., Yu R. Q. Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage. Chinese Chemical Letters, 2010, 21(12): 1482-1486.
37. Zhang Y., Wang H.,* Nie J. F., Zhang Y. W., Shen G. L.,* Yu. R. Q. Individually addressable microelectrode arrays fabricated with gold-coated pencil graphite particles for multiplexed and high sensitive impedance immunoassays. Biosensors and Bioelectronics, 2009, 25(1): 34-40.
38. Wu H. L.*, Nie J. F., Yu Y. J., Yu. R. Q. Multi-way chemometric methodologies and applications: A central summary of our research work (邀請綜述). Analytica Chimica Acta, 2009, 650: 131-142.
39. Zhang Y., Wang H.,* Nie J. F., Zhou H., Shen G. L.*, Yu R. Q. Mussel-inspired fabrication of encoded polymer films for electrochemical identification. Electrochemistry Communication, 2009, 11: 1936-1939.
40. OuYang L. Q., Wu H. L.*, Nie J. F., Zhang Y., Zou H. Y., Fu H. Y., Yu R. Q. Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm. Analytica Chimica Acta, 2009, 650: 160-166.
41. Zou H. Y., Wu H. L.*, OuYang L. Q., Zhang Y., Nie J. F., Fu H. Y., Yu R. Q. Fluorescent quantification of terazosin hydrochloride content in human plasma and tablets using second-order calibration based on both parallel factor analysis and alternating penalty trilinear decomposition. Analytica Chimica Acta, 2009, 650: 143-149.
42. Zhu S. H., Wu H. L.*, Xia A. L., Nie J. F., Bian Y. C., Cai C. B., Yu R. Q, Excitation-emission-kinetic fluorescence coupled with third-order calibration for quantifying carbaryl and investigating the hydrolysis in effluent water. Talanta, 2009, 77: 1640-1646.
43. Wang X. M., Wu H. L.,* Nie J. F., Yu R. Q. Rapid determination of bitertanol content in banana using three-dimensional fluorescence coupled with second-order calibration. Chinese Journal of Analytical Chemistry, 2009, 37: 811-816.
44. Li Y. N., Wu H. L.,* Nie J. F., Li S. F., Yu Y. J., Zhang S. R., Yu R. Q. Interference-free determination of abscisic acid and gibberellin in plant samples by using excitation-emission matrix fluorescence based on oxidation derivatization coupled with second-order calibration methods. Analytical Methods, 2009, 1: 115-122.
45. Li Y. N., Wu H. L.,* Zhang S. R., Nie J. F., Yu Y. J., Wang X. M., Yu R. Q. Determination of indole-3-Acetic acid in soil using excitation-emission matrix fluorescence with trilinear decomposition-based calibration methods. Analytical Sciences, 2009, 25: 83-88.
46. Zou H. Y., Wu H. L.,* Zhang Y., Li S. F., Nie J. F., Fu H. Y., Yu R. Q. Studying the interaction of pirarubicin with DNA and determining pirarubicin in human urine samples: Combining excitation-emission fluorescence matrices with second-order calibration methods. Journal of Fluorescence, 2009, 6: 955-966.
47. Li S. F., Wu H. L.,* Xia A L., Zhu S. H., Nie J. F., Yu R. J., Yu R. Q. Quantitative analysis of epinephrine in human plasma samples using kinetic fluorometric method combined with second-order calibration. Analytical Sciences, 2009, 25: 1231-1236.
48. Nie J. F., Wu H. L.*, Wang X. M., Zhang Y., Zhu S. H., Yu R. Q. Determination of testosterone propionate in cosmetics using excitation-emission matrix fluorescence based on oxidation derivatization with the aid of second-order calibration methods. Analytica Chimica Acta, 2008, 628: 24-32.
49. Nie J. F., Wu H. L.*, Zhu S. H., Han Q. J., Fu H. Y., Li S. F., Yu R. Q. Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation–emission matrix fluorescence coupled with second-order calibration methods. Talanta, 2008, 75: 1260-1269.
50. Cai C. B., Han Q. J., Tang L. J., Nie J. F., OuYang L. Q., Yu R. Q.* Treating NIR data with orthogonal discrete wavelet transform: Predicting concentrations of a multi-component system through a small-scale calibration set. Talanta, 2008, 77: 822-826.
51. Wang X. M., Wu H. L.*, Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.
52. 王雪梅, 吳海龍*, 聶瑾芳, 李元娜, 于永傑, 俞汝勤. 激發發射熒光二階張量校正算法快速檢測桔子中噻苯咪唑. 中國科學B, 2008, 38: 288-293.
53. Han Q. J., Wu H. L.,* Nie J. F., Xia A L., Zhu S. H., Yu R. Q. Direct determination of reserpine in urine using excitation-emission fluorescence combined with three-way chemometric calibration methodologies. Frontiers of Chemistry in China-Selected Publications from Chinese Universities, 2008, 3: 224-228.
54. Wang X. M., Wu H. L.,* Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.
55. Nie J. F., Wu H. L.*, Xia A. L., Zhu S. H., Bian Y. C., Li S. F., Yu R. Q., Determination of sulpiride in human urine using excitation-emission matrix fluorescence coupled with second-order calibration. Analytical Sciences, 2007, 23: 1377-1382.
